Jelly, 3728 bytes
“ETIANMSURWDKGOHVFaLbPJBXCYZQ”iⱮḃ2FŒḂØAŻŻ“¡9o|çṫ¡X1ỴỌġQ’œ?iⱮḃ2FŒḂ
ØA The uppercase alphabet.
ŻŻ Prepend two zeroes.
“¡9o|çṫ¡X1ỴỌġQ’œ? Get the 73540211105102870315464559332nd permutation.
(= “ETIANMSURWDKGOHVF0L0PJBXCYZQ”)
iⱮ Find indices of input letters in this list.
ḃ2 Bijective base 2: map [1,2,3,4,5…] to
[1], [2], [1,1], [1,2], [2,1], …
F Flatten.
ŒḂ Is palindrome?
I wrote this answer looking at one of these (read the rows from right-to-left, and you get my magic string!):