Ruby, 206 200 199

q,i,*R=*-2..27
puts"#{i+=1}: #{$.,s=(-2..q).map{x=R.map{|j|!s||rand<0.05?[*?A..?Z,' '].sample: s[j]};[R.count{|i|x[i]=='METHINKS IT IS LIKE A WEASEL'[i]},x]}.max;q=97;s.join} -- score: #$."until$.>27

The first line is simply a fancy way to define q=-2, i=-1, and R=(0..27).to_a. All the work is done in the 2nd line:

puts"..."until$.>27 # Prints the string in quotes until we reach the desired score
     ^
     |
 +---+
 |
"#{i+=1}: #{...} -- score: #$."
   ^        ^               ^  
   +--------|---------------|-- Generation counter
 +----------+---------------|-- Current string
 |                          +-- Score of current string (interpolates the `$.` variable)
 |   
 #{$.,s=(-2..q).map{...}.max;q=97;s.join} # Generate the score & string
   ^         ^  ^   ^    ^   ^    ^
   +---------|--|---|----|---|----|------ Store the score; this variable makes
             |  |   |    |   |    |       string interpolation shorter.
             +--|---|----|---+----|------ `q` automatically takes care of generating
                |   |    |        |        the string vs randomizing the string.
                +---|----|--------|------  Make 100 (or 1 the first time) strings,
                    |    |        |        and compute their score.
                    |    +--------|------- Take the string with the max score.
 +------------------+             +------- `s` is stored as an array
 |
 x=R.map{...};[R.count{...},x] # Compute string and its score, store in array
   ^     ^    ^^       ^
   +-----|----|+-------|------ `R` is 0..27, we use the constant to save chars.
         |    +--------|------ `max` orders by first element, then second. We clearly want
         |             |       the highest score, so make the score first.
 +-------+-------------|------ Generate the string, store in `x`.
 |                     +------ Count the number of chars that overlap with 'METHINKS...'
 |                     |
 |                    {|i|x[i]=='METHINKS IT IS LIKE A WEASEL'[i]}
{|j|!s||rand<0.05?[*?A..?Z,' '].sample: s[j]}
    ^   ^         ^             ^       ^
    +---+---------|-------------|-------|---- 5% chance of randomizing, or 100% for
                  |             |       |     first string.
                  +-------------+-------|---- Sample from alphabet + ' '.
                                        +---- Don't alter the string 95% of the time