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2 of 2 deleted 88 characters in body

C# (94 characters)

string I(string i){int s=0,j=0;for(;j<12;)s+=(i[j]-48)*(j++%2<1?1:3);return i+((10-s%10)%10);}

With linebreaks/whitespace for readability:

string I(string i) 
{ 
    int s = 0, j = 0;
    for (; j < 12; )
        s += (i[j] - 48) * (j++ % 2 < 1 ? 1 : 3); 
    return i + ((10 - s % 10) % 10); 
}

Tested on several ISBNs from books on my shelf, so I know it's working!