2 added 412 characters in body; edited body
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Python3

220239 Chars

Can do 10000 in ~3.2 seconds (Ideone cuts me off at 8 seconds, i'm sure it'll take longer than 10secs though :( )

from functools import *
N=100
r=range
s=(p for p in r(2,N)if all(p%n>0for n in r(2,p)))
f=lambda n,x:n//x+(n//x>0and f(n//x,x)or 0)
e=list([p,f(N,p)]for p in s)
e[0][1]-=e[2][1]
e[2][1]=0
print(reduce(lambda x,y:x*y,map(lambda x:x[0]**x[1],e))%10)

Python2.6

299 Chars (a bit faster)

from itertools import *
N=100000
r=xrange
def s(c=count(2)):
        while 1:p=c.next();c=ifilter(p.__rmod__,c);yield p
f=lambda n,x:n//x+(n//x>0and f(n//x,x)or 0)
e=[[p,f(N,p)]for p in takewhile(lambda x:x<N,s())]
e[0][1]-=e[2][1]
e[2][1]=0
print(reduce(lambda x,y:x*y,map(lambda x:pow(x[0],x[1],10),e))%10)

Python3

220 Chars

Can do 10000 in ~3.2 seconds (Ideone cuts me off at 8 seconds, i'm sure it'll take longer than 10secs though :( )

from functools import *
N=100
r=range
s=(p for p in r(2,N)if all(p%n>0for n in r(2,p)))
f=lambda n,x:n//x+(n//x>0and f(n//x,x)or 0)
e=list([p,f(N,p)]for p in s)
e[0][1]-=e[2][1]
e[2][1]=0
print(reduce(lambda x,y:x*y,map(lambda x:x[0]**x[1],e))%10)

Python3

239 Chars

Can do 10000 in ~3.2 seconds (Ideone cuts me off at 8 seconds, i'm sure it'll take longer than 10secs though :( )

from functools import *
N=100
r=range
s=(p for p in r(2,N)if all(p%n>0for n in r(2,p)))
f=lambda n,x:n//x+(n//x>0and f(n//x,x)or 0)
e=list([p,f(N,p)]for p in s)
e[0][1]-=e[2][1]
e[2][1]=0
print(reduce(lambda x,y:x*y,map(lambda x:x[0]**x[1],e))%10)

Python2.6

299 Chars (a bit faster)

from itertools import *
N=100000
r=xrange
def s(c=count(2)):
        while 1:p=c.next();c=ifilter(p.__rmod__,c);yield p
f=lambda n,x:n//x+(n//x>0and f(n//x,x)or 0)
e=[[p,f(N,p)]for p in takewhile(lambda x:x<N,s())]
e[0][1]-=e[2][1]
e[2][1]=0
print(reduce(lambda x,y:x*y,map(lambda x:pow(x[0],x[1],10),e))%10)
1
source | link

Python3

220 Chars

Can do 10000 in ~3.2 seconds (Ideone cuts me off at 8 seconds, i'm sure it'll take longer than 10secs though :( )

from functools import *
N=100
r=range
s=(p for p in r(2,N)if all(p%n>0for n in r(2,p)))
f=lambda n,x:n//x+(n//x>0and f(n//x,x)or 0)
e=list([p,f(N,p)]for p in s)
e[0][1]-=e[2][1]
e[2][1]=0
print(reduce(lambda x,y:x*y,map(lambda x:x[0]**x[1],e))%10)