Edit: Now that the rules have been modified, this approach is disqualified. I'm going to leave it here in case anyone is interested until I eventually getting around to modifying it for the new rules.
Python: 277 Characters
I'm pretty sure that the generalized version of this problem is NP-Hard, and the question didn't require finding the fastest solution, so here's a brute-force method of doing it:
import itertools,string
w=[w.lower()[:-1] for w in open('w') if len(w)==6]
v=-1
for l in itertools.product(itertools.combinations(string.ascii_lowercase,10),repeat=5):
c=sum(map(lambda d:sum(map(lambda i:i[0] in i[1],zip(d,l)))==5,w))
if c>v:
v=c
print str(c)+" "+str(l)
Note that I renamed the word list file to just "w" to save a few characters.
The output is the number of words that are possible from a given configuration followed by the configuration itself:
34 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'))
38 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'k'))
42 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'l'))
45 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'n'))
50 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'r'))
57 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 's'))
60 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'k', 's'))
64 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'l', 's'))
67 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'n', 's'))
72 (('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'i', 'j'), ('a', 'b', 'c', 'd', 'e', 'f', 'g', 'h', 'r', 's'))
...
The last line of output before the program terminates is guaranteed to be the optimal solution.